Cancer Immunotherapy Research & Advanced Training

HKU - QIMR Berghofer, HK & Australia

ZeShan Foundation has been a long-time supporter of the cutting-edge cancer research and training carried out in the collaboration between Australia’s Queensland Berghofer Medical Research Institute (QIMR Berghofer) and Hong Kong’s Li Ka Shing Faculty of Medicine, The University of Hong Kong. The transfer of knowledge and technology between these institutions has provided Nasopharyngeal Carcinoma patients in Hong Kong and Australia with access to ground-breaking cancer treatment, as well as training to Hong Kong post-doctoral fellows in the efforts to build up local capacity in cancer research and treatment.

“Heal Thyself”: Immunotherapy for “Cantonese tumor” 

Nasopharyngeal Carcinoma (NPC 鼻咽癌) is an aggressive upper respiratory tract cancer common in East Asia. The 6th most common cancer among Hong Kong males, it’s prevalence in Southern China resulted in the nickname “Cantonese tumor” (廣東瘤). Within the focal area of NPC, the cross-institution research targeted their research on the development of immunotherapy treatment (免疫注射療法), a cell-based treatment that prepares a patient’s own immune system to fight the cancer. At the time of development, it was hoped that immunotherapy would be more effective in treating NPC in comparison to standard cancer treatment such as chemotherapy and radiotherapy, and at the same time avoid serious side effects of deafness and loss of taste.

Through their research, scientists resolved to extract killer T-cells, a type of white blood cell widely known as the “cancer assassin”, and prime them in a laboratory setting. Once infused back into the patient’s bloodstream, the “primed” cells are able to target and attack malignant cells from the Epstein-Barr (EBV) virus in NPC tumour cells while leaving normal ones intact.

While immunotherapy was a relatively new form of treatment, experts such as Prof. Roy Herbst, chief of medical oncology at Yale Cancer Centre in the US, had expressed in media interviews the hope that it could potentially replace chemotherapy as the standard cancer treatment within five years.

Phase I Clinical Trial (2009-2012)

In 2008, ZeShan first supported the Phase I clinical trial of this research. The trial took place between 2009 to 2012, recruiting 30 late-stage NPC patients from Queen Mary Hospital in Hong Kong. The results demonstrated the safety and effectiveness of the developed treatment, improving life expectancy to an overall survival rate of 523 days compared to the 220 days for patients who did not receive the treatment.

 

Phase II Clinical Trial & Post-Doctoral Fellowship (2015-2018)

In 2015, ZeShan continued its support to the second phase clinical trial of this collaboration. The trial began in September of 2015 and was completed in 2018, throughout which immunotherapy treatment was offered to another 30 patients, in this phase targeting patients in earlier stages of NPC in both Hong Kong and Australia. Patients were given up to 6 killer T-cell infusions over 12 weeks and consistently monitored, but were given standard treatment if their diseases progressed.

One element in this collaboration was a four-month advanced training for Hong Kong post-doctoral fellows to master scientific techniques of producing clinical grade killer T-cells, ensuring a solid foundation for further development of local talent in research and clinical care. The training was conducted at QIMR Berghofer’s manufacturing facility, Q-Gen Cell Therapeutics, which was the first facility in Australia to be granted regulatory approval by the country’s Therapeutic Goods Administration to prepare clinical grade T-cell therapies. This magnifies the hope that Hong Kong could eventually set up its very own accredited laboratory, which would allow the city to prepare its own T-cells rather than having them transported between Australia and Hong Kong.

MOU Signing Ceremony

On 28th August 2015, the two institutions signed a memorandum of understanding (MOU) outlining the convergence and collaboration over cutting-edge cancer research and training, supported by ZeShan Foundation. The ceremony was attended by His Excellency the Governor of Queensland, the Honourable Paul de Jersey AC, among other guests. Mr. Roy Chen, Director of ZeShan, delivered a speech on behalf of the foundation.

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“At ZeShan, our philosophy of giving has always been underpinned by three guiding principles: Strategic Philanthropy, Lasting Impact, and Effective Partnership. We have seen all three come together wonderfully in this project. By supporting cutting-edge research by two leading medical research institutions, we hope to help create maximum impact with our funding.”
——Mr. Roy Chen, Director, ZeShan Foundation

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When an unknown printer took a galley of type and scrambled it to make a type specimen book.

Neque porro quisquam est qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit…Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

When an unknown printer took a galley of type and scrambled it to make a type specimen book. It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Photos Grid for Heading 02

Placeholder image
  • Tab 1
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Inside Tab Heading 01 H4

It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

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Geron-Infusion Education (Phase 1)

HKU & PolyU, Hong Kong

An ageing population has shifted global demographics, in turn creating demand for diverse professionals who possess both the knowledge of ageing consumers’ interests and characteristics, and the necessary skills to adapt to their service and product needs. Incorporating ageing-related content into curricula has been found to be effective in enabling students in diverse disciplines to acquire the knowledge necessary to meet these changing societal needs, which place universities in a critical position to respond to ageing populations through new approaches in teaching, research, and community engagement.

In support of the cultivation of gerontology education and workforce development, the Geron-Infusion Education (GIE) initiative was jointly developed and implemented in September 2018 by the Hong Kong Polytechnic University under the Infusion Active Ageing Education project (GIE-IAAE) and the University of Hong Kong under the Campus Ageing Mix Project for University Students (GIE-CAMPUS). The GIE initiative adopted a ‘soft-socialisation approach’, encouraging academic staff to bring active ageing content into their curricula, while also integrating research into the process of feasibility testing and emphasizing the systematic evaluation of impact at the individual, departmental, and institutional levels.

Research objectives

1)       Identify and form a group of scholar leaders in the university to initiate Geron-Infusion activities through innovative programmes.

2)       Test the feasibility of the ageing infusion approaches to equip students with gerontology knowledge and skills.

3)       Promote the integration of gerontology (active ageing infusion education) into formal curricula in different disciplines at the university.

4)       Enhance the university’s institutional capacity to identify innovative ways to nurture future academic and social leaders to face an ageing society in Hong Kong and globally.

Geron-Infusion education models

In this 2-year pilot study, two theoretical GIE models were developed and tested, each designed to suit the institutional context of PolyU and HKU respectively.

An action-oriented approach, the PolyU IAAE model encompasses four sequential components: 1) Identification of academic champions, who are taught the benefits and value of the approach in promoting their application of ageing-related knowledge and skills in their disciplines; 2) Active infusion of related educational content into course curricula, with gerontology experts and academic champions co-creating inter-generational and discipline-specific educational activities; 3) Activity implementation; and (4) Evaluation.

Taking on an evidence-based approach, the GIE-CAMPUS presents Geron-Infusion in a three-tiered concentric model, extending outward from curricular, to institutional, then societal. At the curricular level are four pillars: 1) intergenerational contact-based education, 2) multilayer, nested teaching and learning activities; 3) collaborative leadership, and 4) stakeholder partnership. The next tier emphasizes four aspects of institutional buy-in: 1) mission and vision alignment, 2) supportive educational infrastructure, 3) faculty champions engagement, and 4) student upholding. Finally, the societal tier refers to the societal impacts of population ageing. Six strategies were used to aid the implementation of the GIE-CAMPUS model: 1) a community-based participatory approach, 2) accumulating good practice and reusable teaching and learning resources, 3) maintaining relationships and communication with stakeholders, 4) partnering and co-creating with champions on innovative curricular activities, 5) university and departmental leadership buy-in, and 6) sustaining and motivating Geron-Infusion with additional resources.

Evaluation Methodology

Faculty were identified and nurtured to take on the role as leaders and champions of the GIE project, who through in-depth interviews, evaluated changes in learning outcomes and curricula throughout the initiative.

Pre- and post- course questionnaires were administered to students to evaluate the effectiveness of GIE, which targeted four factors: 1) knowledge about ageing measured by Palmore’s Facts on Ageing Quiz, 2) gerontological skills, 3) attitude towards older people measured by the Chinese version of Kogan’s Attitude Toward Older People, and 4) professional interest in working with older people.

Exploring impact beyond the institutional setting, a “Productive Interactions” framework was developed to assess the societal impacts of GIE by measuring the direct and indirect interactions between different stakeholders. An interaction is considered productive when it leads to efforts by stakeholders to apply their research to broader societal goals.

Results 

Together, the PolyU IAAE and HKU CAMPUS engaged 18 faculty members from 11 disciplines, who integrated ageing-related content into 13 courses. Faculty champions gave positive feedback towards GIE regarding its relevance and benefits, expressing enthusiasm towards a continued improvement and implementation of GIE in their respective courses.

Between 2018 and 2020, the GIE reached a total of 643 students, of which 396 completed both pre- and post-course questionnaires, resulting in a response rate of 61.6%. Results from both institutions indicate that after the implementation of GIE, significant improvements were observed in gerontological skills, attitudes towards older people, and professional interest in working with older people. The two-year project enhanced opportunities for students to experience ageing-related teaching and learning, as well as to have direct contact with older adults and community stakeholders. The GIE had equipped students to become competent workforce professionals in an ageing society, and has strengthened the formal curricula of different academic departments in ways that align with ongoing socio-demographic changes.

Beyond infusing active ageing content and teaching methods into curricula, the initiative involved the placement of over 200 older adults into formal teaching and learning settings. This has fostered collaboration with local communities, including elderly services agencies, NGOs, industries, enterprises, secondary schools, and the general public, as well as regional and international organisations and research networks.

More broadly, research teams, faculty champions, and senior champions have successfully nurtured ageing literacy by accumulating innovative teaching and learning resources through the GIE. Resulting is the institutionalisation of gerontological competencies through the launch of a new Common Core cluster and transdisciplinary minor, The Human Lifespan.

Conclusion

The GIE is the first initiative in the world to use an ageing-infusion education approach to bring active ageing content into a diverse range of disciplinary curricula at higher institutions. The GIE pilot implemented at PolyU and HKU achieved all four of its objectives, and has made significant progress in increasing sensitivity, interest, and exposure to Geron-Infusion, as well as in advancing the leadership and capacity of tertiary institutions to respond purposefully to an ageing demographic worldwide. Both qualitative and quantitative data provide evidence in support of the GIE project’s impacts on faculty, students, institutions, and the community.

Tested under two different institutional contexts with varying levels of institutional and faculty management buy-in, the success of the two piloted GIE models—IAAE and CAMPUS—demonstrate its viability as pragmatic frameworks for Geron-Infusion curricula. Findings from students and faculty members demonstrate that both models are effective to some extent, yet highlight the importance of adaptability to the institutional context and capacity.

Contributing to its success, the PolyU IAAE and HKU CAMPUS overlapped in three factors: 1) co-creation of Geron-Infusion activities by the research team and faculty champions; 2) bringing older citizens into the classroom, whereby students have direct, personal, and positive contact with older people; and 3) building partnerships with diverse local stakeholders including professional parties, enterprises, community agencies, and organisations.

Identified challenges that impede the GIE’s ability to succeed include faculty resistance to the concept or the execution of Geron-Infusion education, low response from students in data collection, management of senior champions, and civil unrest and turbulence due to the 2019 social movements and the COVID-19 pandemic. Although some faculty members endorsed the continuation of Geron-Infusion in their future curricula, it is uncertain how long it can be sustained due to faculty and course coordinator turnover, unprecedented situations, declining faculty buy-in, and/or competing priorities. Moreover, rather than engaging with faculty members individually, knowledge and experience sharing should be encouraged between faculty champions, strengthening interconnections and communication among GIE participants within and across different universities.

Consolidating identified good practices, a public online teaching and learning e-toolkit on Geron-Infusion education has been developed to support faculty members from different disciplines in designing and downloading their self-created Geron-Infusion education plans. In addition to sharing insight on feasibility, implementation strategies, benefits, and impacts to the various stakeholder groups in Hong Kong and international networks, the GIE initiative can also bring together global initiatives for identifying and refining future Geron-Infusion and age-inclusive approaches in higher education in Asia and worldwide to meet the opportunities and challenges of ageing populations.

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PolyU-IAA team

Faculty of Law_ Outreach Legal Talks Initiative (OUTLET)_ HKU legal talk

GIE-CAMPU​S project legal talk for older adults in the community, co-organized  student-led and extracurricular project Outreach Legal Talks Initiative of Faculty of Law, HKU.

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Quantifying Hepatitis B and C Burden in Asia

CDA Foundation, Asia

Viral hepatitis continues to be one of the deadliest infections in the world, attributed as the cause of one death every 25 seconds, as well as being identified as the leading cause of liver cancer in the world.  Most cases of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are in Asia, so it is important to quantify the disease burden in Asia to help international agencies, public health organizations and policy-makers develop strategies to eliminate these infections.

Today, there are many treatments to eliminate viral hepatitis.  With the availability of vaccines that can effectively prevent Hepatitis B, many countries have adopted large-scale vaccination practices for infants, one such example being China. Treatment for Hepatitis B has also been developed for patients who had been infected prior to the availability of vaccines, and existing treatments for Hepatitis C can cure patients within the span of 12 weeks.  However, many cases of HBV and HCV still remain untreated to this day.

Since 2018, the ZeShan Foundation has been providing funding to the Center for Disease Analysis Foundation in their efforts to help countries in Asia eliminate hepatitis B and C in the region.  To study and publish a report on the breadth of hepatitis B and C burden across Asia, the CDA Foundation worked closely with Asian countries to collect data on the number of people infected, diagnosed, and treated. In this project, mathematical models were used to estimate the impact of viral hepatitis in Asia, the summary of which is shown below.  From the data collected, an estimate of 188 million people in Asia are infected with hepatitis B (Figure 1) and another 34 million with hepatitis C (Figure 2).  For more details, please view the CDA Foundation’s website:  https://cdafound.org/dashboard/polaris/dashboard.html.

The compiled research reveals that a majority of global HBV- and HCV-related cases of liver cancer and liver related deaths are concentrated in Asia (Figure 3).  This analysis will help Asian countries obtain more funding for the elimination of viral hepatitis, and additionally recruit support from their government to test and treat this population through HBV vaccinations.

An estimate 188 million people in Asia were infected with hepatitis B

Fig. 1  An estimate 188 million people in Asia were infected with hepatitis B

34 million people in Asia were infected with hepatitis C

Fig. 2  34 million people in Asia were infected with hepatitis C

CDA fig 3

Fig. 3  A majority of global HBV- and HCV-related cases of liver cancer and liver related deaths are concentrated in Asia

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When an unknown printer took a galley of type and scrambled it to make a type specimen book.

Neque porro quisquam est qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit…Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

When an unknown printer took a galley of type and scrambled it to make a type specimen book. It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Photos Grid for Heading 02

Placeholder image
  • Tab 1
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Inside Tab Heading 01 H4

It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

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International iPMTCT Summit 2014

Health Bureau, Hainan Province, China

In partnership with the Hainan Bureau of Health and China’s National Center for Women and Children’s Health, ZeShan organized an international roundtable summit on the Integrated Prevention of Mother-to-Child Transmission (iPMTCT) of HIV, HBV and syphilis, which was hosted in Hainan Province in January 2014.

Focusing on public-private partnerships and innovative practices for high-impact outcomes, the Summit brought together a blue-ribbon panel of experts, scholars, practitioners, policy makers, and representatives from major health organizations, including WHO China, WHO Western Pacific Region, UNICEF, UNAIDS, Aaron Diamond AIDS Research Center, and Chinese Center for Disease.

Participants shared insights on lessons learnt and best practices in this field, and debated over the unique challenges of effectively implementing iPMTCT in culturally and demographically diverse settings. Prompted by Hainan’s relatively low HIV prevalence and very high HBV rate (over twice the national average), the discussion inevitably tilted toward exploring effective PMTCT of HBV.

Following the Summit in Sanya, participants went on a field trip to visit local maternal and children’s hospitals and clinics in surrounding villages. Local health officials and practitioners shared their experiences in and views on the healthcare system, in particular focusing on effective approaches to iPMTCT operation in low HIV and high HBV settings.

Emerging as a result of this Summit was the agreement among the UN China network to promote China’s iPMTCT practice around the world as innovative practice, which was decided at the coordinating committee meeting of UN health-related organizations in China held the week following the Hainan Summit.

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When an unknown printer took a galley of type and scrambled it to make a type specimen book.

Neque porro quisquam est qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit…Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

When an unknown printer took a galley of type and scrambled it to make a type specimen book. It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Photos Grid for Heading 02

Placeholder image
  • Tab 1
  • Tab 2
  • Tab 3

Inside Tab Heading 01 H4

It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

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Combating Hepatitis in Western Pacific Region

World Health Organisation Office for the Western Pacific Region (WPRO), Asia

Since 2013, ZeShan Foundation has been providing support to the World Health Organisation Office for the Western Pacific Region (WPRO). ZeShan’s grants aid WPRO in combating viral hepatitis in the region, and includes the allocation of specific support to the China office.

Viral hepatitis is responsible for 1.4 million deaths globally. There are estimated to be 115 million people with chronic hepatitis B (HBV) infection and 14 million with chronic hepatitis C (HCV) infection living in the Western Pacific Region, accounting for 40 % of people burdened with chronic hepatitis B and C across the globe. 

Chronic HBV and HCV is known to lead to the development of cirrhosis and liver cancer over time. With 60% of the worlds’ affected population, the Western Pacific Region has the highest number of deaths caused by liver cancer globally, which is also the 6th top cause of death in the region. Six of the top ten countries with the highest incidence (new annual cases) of liver cancer in the world include Mongolia (highest incidence globally), Viet Nam, Lao People’s Democratic Republic, Cambodia, China and South Korea.  This being said, early testing and treatment can effectively reduce the progression of these diseases and subsequently the risk of development of liver cancer.   

Patient Story (Philippines): https://www.who.int/philippines/news/feature-stories/detail/surviving-hepatitis-b-and-liver-cancer-vhal-s-story

News feature: https://www.montsame.mn/en/read/136120    World Hepatitis Day in Mongolia, 2018

The grant support from ZeShan Foundation has vaulted WPRO into leading the action on viral hepatitis in the Region, and has allowed the organization to establish regional responses in the effort to eliminate viral hepatitis as outlined by the Global Health Sector Strategy for Viral Hepatitis 2016-2021 . With the elimination of viral hepatitis being highlighted within the 2030 Sustainable Development Goals, the Regional Action Plan for Viral Hepatitis in the Western Pacific 2016-2020  has been endorsed by all countries in the Western Pacific Region, which defines specific actions to be taken in order to better understand hepatitis epidemics. The outlined actions include awareness and knowledge building among stakeholders, strengthening public policy, and data generation, which will also be essential factor in the process of enhancing prevention strategies and improving access to affordable screening, diagnosis and treatment of hepatitis B and C.

Figure 1 illustrates the current progress in hepatitis response programmes in the Western Pacific Region, which underscores the critical importance of national leadership, development of national response plans and having data to inform policy and decision making.

Source: WHO Western Pacific Regional Office, January 2021.

Supporting countries to scale up interventions towards hepatitis elimination

The Western Pacific Region has led global efforts in working towards hepatitis elimination. Some of the regional successes include the triple elimination of mother-to-child transmission of HIV, syphilis, and hepatitis B, as well as the scaled up hepatitis testing and treatment encompassed in Universal Health Coverage. See more here in country case studies[1]  [2]   – China, Triple elimination, Mongolia, Malaysia

Links:

Link to overall WPRO hepatitis website: https://www.who.int/westernpacific/health-topics/hepatitis

Building capacity of healthcare providers

It is critical to ensure that healthcare providers are trained to deliver good quality hepatitis care and treatment. WPRO has published Training Modules on Hepatitis B and C Screening, Diagnosis and Treatment[1] in collaboration with the WHO South East Asia Region and other WHO centers.

[1] WPRO-SEARO clinical training modules, published July 28, 2020

https://www.who.int/southeastasia/publications-detail/9789290227472

 WPRO-SEARO clinical modules

https://www.who.int/southeastasia/publications-detail/9789290227472

Raising public awareness on viral hepatitis

To improve awareness around viral hepatitis and its impact on health, WHO offices in all countries work closely with the Ministries of Health and their partners to provide information to the public. Every year, awareness is raised globally through World Hepatitis Day on 28th July.

Link to videos: (snapshot)

Link to video on hepatitis (mash-up) https://youtu.be/Xl1hRjm-Uhk

WPRO-SEARO clinical training modules, published July 28, 2020

https://www.who.int/southeastasia/publications-detail/9789290227472

Philippines: scaling up hepatitis B services during the COVID-19 lockdowns (video World Hepatitis Day 2020): https://www.facebook.com/whophilippines/videos/291155845324695

Malaysia – Yap’s Story: Road to Recovery (a story of HIV and HCV for World AIDS Day 2020):  https://www.youtube.com/watch?v=D-6T-J0Sd10

Malaysia – Silas’s Story: Road to Recovery (World Hepatitis Day 2020):  https://www.youtube.com/watch?v=5aBstAHJ-0M&feature=youtu.be

Viet Nam – Chiến thắng bệnh viêm gan C | Successful fight against hepatitis C (World Hepatitis Day 2020): https://www.youtube.com/watch?v=KjT3r6OCxdY&t=48s

WHO country office China – 肝炎,做好检测,及早治,活出最好的自己 (World Hepatitis Day 2020): https://v.qq.com/x/page/o0530ahwxel.html

WHO country office China –消除歧,消除肝炎 (World Hepatitis Day 2020): https://v.qq.com/x/page/d0530xpdu1y.html

WHO country office Mongolia – World Hepatitis Day 2020: https://www.facebook.com/WHO.MGL/videos/981267499003176

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Heading 02 (H3)

When an unknown printer took a galley of type and scrambled it to make a type specimen book.

Neque porro quisquam est qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit…Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

When an unknown printer took a galley of type and scrambled it to make a type specimen book. It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Photos Grid for Heading 02

Placeholder image
  • Tab 1
  • Tab 2
  • Tab 3

Inside Tab Heading 01 H4

It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

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Supporting Asian Liver Center

Stanford University School of Medicine, United States of America & Hong Kong

ZeShan Foundation has been supporting the Asian Liver Center (ALC) . Founded in 1996 by Dr. Samuel So, a professor of surgery at the Stanford University School of Medicine, ALC is the first non-profit organization in the United States that addresses the high incidence of hepatitis B and liver cancer among Asians and Asian Americans. Since then, ALC has been at the forefront of educational outreach and advocacy efforts in the areas of hepatitis B and liver cancer prevention and treatment, providing valuable resource for both the public and health practitioners.

Partnering with the Hong Kong Hep B Free Foundation, APAVH and ALC launched the first World Hepatitis Day media campaign in the city on 28 July 2011, public service announcements were made on radio, newspaper, magazines and public transportation billboards.  The message of getting tested and vaccinated was well received by the public.

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CCTV: Public Education Campaign

China Central Television, China

Recognizing the impact and reach of national television networks, ZeShan in 2010 underwrote the production of a documentary on the prevention of mother to child transmission of hepatitis B by the China Central Television’s (CCTV) Population program, under the auspices of the National Population and Family Planning Commission.  The documentary was recognized with a special award in November 2010 at the Fifth National Conference on Public Health and Media, co-organized by the Ministry of Health and Tsinghua University. It was premiered on CCTV Channel 1 on November 18, 2010.  Plans are underway to develop an extended version for wider distribution to provincial television networks.

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Scaled-up iPMTCT Demonstration Programs

Centre for Disease Control and Prevention, China

To build on the success of the pilot initiatives, ZeShan stepped up support for integrated prevention of mother-to-child transmission (PMTCT) prevention in 2010. One of the programs being implemented takes place in high prevalence and low income regions of Hubei, Hebei, Xinjiang and Shanxi provinces, and is expected to screen 24,000 pregnant women for HBV, HIV and syphilis, while providing 42,000 people with pre-marital medical screening in the next two years. Emphasis is on building capacity in integrated prevention for local maternal units in partnership with Chinese CDC’s and infectious disease departments. A comprehensive training manual with participation from WHO China is currently in trial use.

Another program, a scaled-up initiative in Yunnan, will continue to integrate HBV, HIV and syphilis in the prevention of mother-to-child transmission in 26 counties of Yunnan province.  The effort is expected to provide screening on HBV and syphilis for up to 146,000 pregnant women.  Spouses and children of those tested positive will also receive screening and counseling services.

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Supporting Asia-Pacific Alliance to Eliminate Viral Hepatitis (APAVH)

APAVH, Asia

ZeShan Foundation was a founding contributor to the Asia and Pacific Alliance to Eliminate Viral Hepatitis(APAVH), a global initiative co-founded by the Asian Liver Center at Stanford University, US CDC and WHO in 2008.  The first global effort to work towards the elimination of viral hepatitis, APAVH aims to create a sustainable public and private partnership to eliminate the transmission of viral hepatitis infection and reduce the stigma and complications of chronic viral hepatitis infection.

Hosted by ZeShan in April 2010, APAVH’s first regional meeting entitled “Learning from China to Enhance Prevention and Control Efforts in Asia” was held in Hong Kong.  Experts shared best practices and lessons learned in China, and how APAVH could address the remaining gaps, from vaccinating susceptible populations that include college students, healthcare workers and migrants, to providing antiviral treatments for the estimated 35 million hepatitis B patients. The first APAVH 2010 regional meeting report has been published as a reference guide to demonstrate China’s leadership role in the Western Pacific Region.

As a demonstration project, APAVH has formed a partnership with the Shandong CDC to develop an evidence-based online training course to raise hepatitis B awareness and improve healthcare providers’ knowledge and practices.   The course consists of three modules covering hepatitis knowledge and vaccination, safe injection practices and physician-patient education.  The online education tool was opened for enrollment in July 2011 at http://knowhbv.org.  Pilot test to evaluate the effectiveness and value of the course has been conducted and a preliminary qualitative analysis shows significant improvement in hepatitis B knowledge.

And as part of the advocacy and education act, the official APAVH website has been launched, providing a centralized resource for global viral hepatitis and liver cancer data, reports and publications.   Researches on hepatitis B and related liver diseases in countries in the Western Pacific and South East Asia regions have been conducted and country profiles are developed and available on https://www.stanfordapavh.org/.  And the first WPRO website on hepatitis B was created in late 2011; meanwhile brochures and posters promoting hepatitis B vaccination were produced and distributed in 8 countries in the region.

With prevalent infection and vast high risk groups, misunderstanding of hepatitis B and discrimination against hepatitis B carries were common in China.  Teaching and learning materials for Chinese citizens would benefit many.  APAVH completed the development of an online animation in Chinese to better inform people in the country about hepatitis B.  The animation covers common questions the public have about the disease, such as ways of transmission, prevention and treatment.  The material can be accessed through APAVH China website and is an important means to clear misunderstandings and discriminations.

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When an unknown printer took a galley of type and scrambled it to make a type specimen book.

Neque porro quisquam est qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit…Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

When an unknown printer took a galley of type and scrambled it to make a type specimen book. It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Photos Grid for Heading 02

Placeholder image
  • Tab 1
  • Tab 2
  • Tab 3

Inside Tab Heading 01 H4

It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

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Related Links

Touching Hearts in Tibet

China

Tibet has a high congenital heart disease rate of around 7%, its cause due to a range of different factors. While operation is considered a standard and effective medical solution to congenital heart disease, hospitals in Tibet are generally not equipped nor staffed for the procedure. Rather, timely diagnosis and treatment can greatly improve children’s survival rate and live a healthy life by beating the odds of congenital heart disease, a leading cause of birth defect-related deaths.

To address this identified need, ZeShan Foundation and Si Yuan Foundation pooled funds to support the “Touching Hearts in Tibet” project. This humanitarian effort included the purchase and installation of a Bi-plane Catheterization laboratory and the construction of a 16-bed paediatric intensive care at the Tibetan People’s Hospital in Lhasa, both the first of its kind at this institution. In the first phase of the project, five Tibetan doctors received training from volunteer doctors from China, Singapore, Malaysia and the United States, whose time and expertise have contributed to the saving of many children’s lives at the facility since the project’s inception. The government contributed $800,000 to put the facility in full operation, which now allows every child up to the age of 18 with congenital heart disease in Tibet to receive free heart care at this institution.

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Heading 02 (H3)

When an unknown printer took a galley of type and scrambled it to make a type specimen book.

Neque porro quisquam est qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit…Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

When an unknown printer took a galley of type and scrambled it to make a type specimen book. It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Photos Grid for Heading 02

Placeholder image
  • Tab 1
  • Tab 2
  • Tab 3

Inside Tab Heading 01 H4

It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

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