Cancer Immunotherapy Research & Advanced Training

HKU - QIMR Berghofer, HK & Australia

ZeShan Foundation has been a long-time supporter of the cutting-edge cancer research and training carried out in the collaboration between Australia’s Queensland Berghofer Medical Research Institute (QIMR Berghofer) and Hong Kong’s Li Ka Shing Faculty of Medicine, The University of Hong Kong. The transfer of knowledge and technology between these institutions has provided Nasopharyngeal Carcinoma patients in Hong Kong and Australia with access to ground-breaking cancer treatment, as well as training to Hong Kong post-doctoral fellows in the efforts to build up local capacity in cancer research and treatment.

“Heal Thyself”: Immunotherapy for “Cantonese tumor” 

Nasopharyngeal Carcinoma (NPC 鼻咽癌) is an aggressive upper respiratory tract cancer common in East Asia. The 6th most common cancer among Hong Kong males, it’s prevalence in Southern China resulted in the nickname “Cantonese tumor” (廣東瘤). Within the focal area of NPC, the cross-institution research targeted their research on the development of immunotherapy treatment (免疫注射療法), a cell-based treatment that prepares a patient’s own immune system to fight the cancer. At the time of development, it was hoped that immunotherapy would be more effective in treating NPC in comparison to standard cancer treatment such as chemotherapy and radiotherapy, and at the same time avoid serious side effects of deafness and loss of taste.

Through their research, scientists resolved to extract killer T-cells, a type of white blood cell widely known as the “cancer assassin”, and prime them in a laboratory setting. Once infused back into the patient’s bloodstream, the “primed” cells are able to target and attack malignant cells from the Epstein-Barr (EBV) virus in NPC tumour cells while leaving normal ones intact.

While immunotherapy was a relatively new form of treatment, experts such as Prof. Roy Herbst, chief of medical oncology at Yale Cancer Centre in the US, had expressed in media interviews the hope that it could potentially replace chemotherapy as the standard cancer treatment within five years.

Phase I Clinical Trial (2009-2012)

In 2008, ZeShan first supported the Phase I clinical trial of this research. The trial took place between 2009 to 2012, recruiting 30 late-stage NPC patients from Queen Mary Hospital in Hong Kong. The results demonstrated the safety and effectiveness of the developed treatment, improving life expectancy to an overall survival rate of 523 days compared to the 220 days for patients who did not receive the treatment.

 

Phase II Clinical Trial & Post-Doctoral Fellowship (2015-2018)

In 2015, ZeShan continued its support to the second phase clinical trial of this collaboration. The trial began in September of 2015 and was completed in 2018, throughout which immunotherapy treatment was offered to another 30 patients, in this phase targeting patients in earlier stages of NPC in both Hong Kong and Australia. Patients were given up to 6 killer T-cell infusions over 12 weeks and consistently monitored, but were given standard treatment if their diseases progressed.

One element in this collaboration was a four-month advanced training for Hong Kong post-doctoral fellows to master scientific techniques of producing clinical grade killer T-cells, ensuring a solid foundation for further development of local talent in research and clinical care. The training was conducted at QIMR Berghofer’s manufacturing facility, Q-Gen Cell Therapeutics, which was the first facility in Australia to be granted regulatory approval by the country’s Therapeutic Goods Administration to prepare clinical grade T-cell therapies. This magnifies the hope that Hong Kong could eventually set up its very own accredited laboratory, which would allow the city to prepare its own T-cells rather than having them transported between Australia and Hong Kong.

MOU Signing Ceremony

On 28th August 2015, the two institutions signed a memorandum of understanding (MOU) outlining the convergence and collaboration over cutting-edge cancer research and training, supported by ZeShan Foundation. The ceremony was attended by His Excellency the Governor of Queensland, the Honourable Paul de Jersey AC, among other guests. Mr. Roy Chen, Director of ZeShan, delivered a speech on behalf of the foundation.

https://zeshanfoundation.org/wp-content/uploads/2021/04/HKU-QIMR-Berghofer-Cancer-Immunotherapy-3.jpg
https://zeshanfoundation.org/wp-content/uploads/2021/04/HKU-QIMR-Berghofer-Cancer-Immunotherapy-1-640x427.jpg

“At ZeShan, our philosophy of giving has always been underpinned by three guiding principles: Strategic Philanthropy, Lasting Impact, and Effective Partnership. We have seen all three come together wonderfully in this project. By supporting cutting-edge research by two leading medical research institutions, we hope to help create maximum impact with our funding.”
——Mr. Roy Chen, Director, ZeShan Foundation

XXXXXXXXXXXXXXXXXXXXXXXXXX

XXXXXXXXXXXXXXXX

XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

XXXXXXXXXXXXXXXX

Heading 02

Heading 02 (H3)

When an unknown printer took a galley of type and scrambled it to make a type specimen book.

Neque porro quisquam est qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit…Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

When an unknown printer took a galley of type and scrambled it to make a type specimen book. It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Photos Grid for Heading 02

Placeholder image
  • Tab 1
  • Tab 2
  • Tab 3

Inside Tab Heading 01 H4

It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy. Various versions have evolved over the years, sometimes by accident, sometimes on purpose (injected humour and the like).

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry’s standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.

0123456789001234567890
Counter 01

Related Links

Geron-Infusion Education (Phase 1)

HKU & PolyU, Hong Kong

An ageing population has shifted global demographics, in turn creating demand for diverse professionals who possess both the knowledge of ageing consumers’ interests and characteristics, and the necessary skills to adapt to their service and product needs. Incorporating ageing-related content into curricula has been found to be effective in enabling students in diverse disciplines to acquire the knowledge necessary to meet these changing societal needs, which place universities in a critical position to respond to ageing populations through new approaches in teaching, research, and community engagement.

In support of the cultivation of gerontology education and workforce development, the Geron-Infusion Education (GIE) initiative was jointly developed and implemented in September 2018 by the Hong Kong Polytechnic University under the Infusion Active Ageing Education project (GIE-IAAE) and the University of Hong Kong under the Campus Ageing Mix Project for University Students (GIE-CAMPUS). The GIE initiative adopted a ‘soft-socialisation approach’, encouraging academic staff to bring active ageing content into their curricula, while also integrating research into the process of feasibility testing and emphasizing the systematic evaluation of impact at the individual, departmental, and institutional levels.

Research objectives

1)       Identify and form a group of scholar leaders in the university to initiate Geron-Infusion activities through innovative programmes.

2)       Test the feasibility of the ageing infusion approaches to equip students with gerontology knowledge and skills.

3)       Promote the integration of gerontology (active ageing infusion education) into formal curricula in different disciplines at the university.

4)       Enhance the university’s institutional capacity to identify innovative ways to nurture future academic and social leaders to face an ageing society in Hong Kong and globally.

Geron-Infusion education models

In this 2-year pilot study, two theoretical GIE models were developed and tested, each designed to suit the institutional context of PolyU and HKU respectively.

An action-oriented approach, the PolyU IAAE model encompasses four sequential components: 1) Identification of academic champions, who are taught the benefits and value of the approach in promoting their application of ageing-related knowledge and skills in their disciplines; 2) Active infusion of related educational content into course curricula, with gerontology experts and academic champions co-creating inter-generational and discipline-specific educational activities; 3) Activity implementation; and (4) Evaluation.

Taking on an evidence-based approach, the GIE-CAMPUS presents Geron-Infusion in a three-tiered concentric model, extending outward from curricular, to institutional, then societal. At the curricular level are four pillars: 1) intergenerational contact-based education, 2) multilayer, nested teaching and learning activities; 3) collaborative leadership, and 4) stakeholder partnership. The next tier emphasizes four aspects of institutional buy-in: 1) mission and vision alignment, 2) supportive educational infrastructure, 3) faculty champions engagement, and 4) student upholding. Finally, the societal tier refers to the societal impacts of population ageing. Six strategies were used to aid the implementation of the GIE-CAMPUS model: 1) a community-based participatory approach, 2) accumulating good practice and reusable teaching and learning resources, 3) maintaining relationships and communication with stakeholders, 4) partnering and co-creating with champions on innovative curricular activities, 5) university and departmental leadership buy-in, and 6) sustaining and motivating Geron-Infusion with additional resources.

Evaluation Methodology

Faculty were identified and nurtured to take on the role as leaders and champions of the GIE project, who through in-depth interviews, evaluated changes in learning outcomes and curricula throughout the initiative.

Pre- and post- course questionnaires were administered to students to evaluate the effectiveness of GIE, which targeted four factors: 1) knowledge about ageing measured by Palmore’s Facts on Ageing Quiz, 2) gerontological skills, 3) attitude towards older people measured by the Chinese version of Kogan’s Attitude Toward Older People, and 4) professional interest in working with older people.

Exploring impact beyond the institutional setting, a “Productive Interactions” framework was developed to assess the societal impacts of GIE by measuring the direct and indirect interactions between different stakeholders. An interaction is considered productive when it leads to efforts by stakeholders to apply their research to broader societal goals.

Results 

Together, the PolyU IAAE and HKU CAMPUS engaged 18 faculty members from 11 disciplines, who integrated ageing-related content into 13 courses. Faculty champions gave positive feedback towards GIE regarding its relevance and benefits, expressing enthusiasm towards a continued improvement and implementation of GIE in their respective courses.

Between 2018 and 2020, the GIE reached a total of 643 students, of which 396 completed both pre- and post-course questionnaires, resulting in a response rate of 61.6%. Results from both institutions indicate that after the implementation of GIE, significant improvements were observed in gerontological skills, attitudes towards older people, and professional interest in working with older people. The two-year project enhanced opportunities for students to experience ageing-related teaching and learning, as well as to have direct contact with older adults and community stakeholders. The GIE had equipped students to become competent workforce professionals in an ageing society, and has strengthened the formal curricula of different academic departments in ways that align with ongoing socio-demographic changes.

Beyond infusing active ageing content and teaching methods into curricula, the initiative involved the placement of over 200 older adults into formal teaching and learning settings. This has fostered collaboration with local communities, including elderly services agencies, NGOs, industries, enterprises, secondary schools, and the general public, as well as regional and international organisations and research networks.

More broadly, research teams, faculty champions, and senior champions have successfully nurtured ageing literacy by accumulating innovative teaching and learning resources through the GIE. Resulting is the institutionalisation of gerontological competencies through the launch of a new Common Core cluster and transdisciplinary minor, The Human Lifespan.

Conclusion

The GIE is the first initiative in the world to use an ageing-infusion education approach to bring active ageing content into a diverse range of disciplinary curricula at higher institutions. The GIE pilot implemented at PolyU and HKU achieved all four of its objectives, and has made significant progress in increasing sensitivity, interest, and exposure to Geron-Infusion, as well as in advancing the leadership and capacity of tertiary institutions to respond purposefully to an ageing demographic worldwide. Both qualitative and quantitative data provide evidence in support of the GIE project’s impacts on faculty, students, institutions, and the community.

Tested under two different institutional contexts with varying levels of institutional and faculty management buy-in, the success of the two piloted GIE models—IAAE and CAMPUS—demonstrate its viability as pragmatic frameworks for Geron-Infusion curricula. Findings from students and faculty members demonstrate that both models are effective to some extent, yet highlight the importance of adaptability to the institutional context and capacity.

Contributing to its success, the PolyU IAAE and HKU CAMPUS overlapped in three factors: 1) co-creation of Geron-Infusion activities by the research team and faculty champions; 2) bringing older citizens into the classroom, whereby students have direct, personal, and positive contact with older people; and 3) building partnerships with diverse local stakeholders including professional parties, enterprises, community agencies, and organisations.

Identified challenges that impede the GIE’s ability to succeed include faculty resistance to the concept or the execution of Geron-Infusion education, low response from students in data collection, management of senior champions, and civil unrest and turbulence due to the 2019 social movements and the COVID-19 pandemic. Although some faculty members endorsed the continuation of Geron-Infusion in their future curricula, it is uncertain how long it can be sustained due to faculty and course coordinator turnover, unprecedented situations, declining faculty buy-in, and/or competing priorities. Moreover, rather than engaging with faculty members individually, knowledge and experience sharing should be encouraged between faculty champions, strengthening interconnections and communication among GIE participants within and across different universities.

Consolidating identified good practices, a public online teaching and learning e-toolkit on Geron-Infusion education has been developed to support faculty members from different disciplines in designing and downloading their self-created Geron-Infusion education plans. In addition to sharing insight on feasibility, implementation strategies, benefits, and impacts to the various stakeholder groups in Hong Kong and international networks, the GIE initiative can also bring together global initiatives for identifying and refining future Geron-Infusion and age-inclusive approaches in higher education in Asia and worldwide to meet the opportunities and challenges of ageing populations.

https://zeshanfoundation.org/wp-content/uploads/2021/04/IAA-640x480.jpg

PolyU-IAA team

Faculty of Law_ Outreach Legal Talks Initiative (OUTLET)_ HKU legal talk

GIE-CAMPU​S project legal talk for older adults in the community, co-organized  student-led and extracurricular project Outreach Legal Talks Initiative of Faculty of Law, HKU.

XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
  • Tab 1
  • Tab 2
  • Tab 3

Inside Tab Heading 01 H4

0123456789001234567890
Counter 01

© Copyright 2021, ZeShan Foundation  | Terms and Conditions | Privacy Policy